Partial functor

Hi, A partial functor from C to D is given by a subcategory S of C and a functor from S to D. What is the appropriate notion of natural transformation between partial functors that would allow to turn small categories, partial functors and those "natural transformations" into a bicategory? The difficulty is that two partial functors from C to D might not have the same definition domain. [For admin and other information see: http://www.mta.ca/~cat-dist/ ]